Collective resonances in plasmonic crystals: Size matters

Periodic arrays of metallic nanoparticles may sustain Surface Lattice Resonances (SLRs), which are collective resonances associated with the diffractive coupling of Localized Surface Plasmon Resonances (LSPRs). By investigating a series of arrays with varying number of particles, we traced the evolution of SLRs to its origins. Polarization resolved extinction spectra of arrays formed by a few nanoparticles were measured, and found to be in very good agreement with calculations based on a coupled dipole model. Finite size effects on the optical properties of the arrays are observed, and our results provide insight into the characteristic length scales for collective plasmonic effects: for arrays smaller than 5 x 5 particles, the Q-factors of SLRs are lower than those of LSPRs; for arrays larger than 20 x 20 particles, the Q-factors of SLRs saturate at a much larger value than those of LSPRs; in between, the Q-factors of SLRs are an increasing function of the number of particles in the array.Comment: 4 figure

Will the Sustainable Development Goals address the links between poverty and the natural environment?

The relationships between the natural environment and poverty have been a central theme in the sustainability and development literatures. However, they have been less influential in mainstream international development and conservation policies, which often neglect or fail to adequately address these relationships. This paper examines how the Sustainable Development Goals (SDGs) may influence the framing of environment-poverty relationships. We argue that the SDGs’ comprehensive nature could provide an opportunity for better environment-poverty integration. To realise this potential, SDG-related activities will need to challenge the institutional status quo; transform how we measure, understand and implement development; design interventions that reflect local visions of development; make trade-offs between SDGs explicit; and address ultimate drivers of environmental degradation and poverty.Cambridge Humanities Research Gran

Spatial effects in stated preference studies for environmental valuation

Bergh, J.C.J.M. van den [Promotor]Brouwer, R. [Promotor

Predicting clinical outcomes of cancer patients with a p53 deficiency gene signature

The tumor suppressor p53, encoded by the TP53 gene, is mutated or nullified in nearly 50% of human cancers. It has long been debated whether TP53 mutations can be utilized as a biomarker to predict clinical outcomes of cancer patients. In this study, we applied computational methods to calculate p53 deficiency scores (PDSs) that reflect the inactivation of the p53 pathway, instead of TP53 mutation status. Compared to TP53 mutation status, the p53 deficiency gene signature is a powerful predictor of overall survival and drug sensitivity in a variety of cancer types and treatments. Interestingly, the PDSs predicted clinical outcomes more accurately than drug sensitivity in cell lines, suggesting that tumor heterogeneity and/or tumor microenvironment may play an important role in predicting clinical outcomes using p53 deficiency gene signatures

Digital documentation and analysis of Native American rock art and Euro-American historical inscriptions from the Canyons of the Ancients National Monument, Colorado

Szczegółowa fotogrametria i skanowanie laserowe 3D sztuki naskalnej, badania geofizyczne i wykopaliska sondażowe przeprowadzone w Painted Hand Petroglyph Panel, ogromnym stanowisku ze sztuką naskalną w południowo-zachodniej części Kolorado w USA, ujawniły nowe informacje na temat sytuacji kulturowej na prekolumbijskim i historycznym Południowym Zachodzie Ameryki Północnej.Detailed photogrammetry and 3D laser scanning of rock art, geophysics research and sondage excavations conducted at the Painted Hand Petroglyph Panel, a large rock art site in south-western Colorado, USA, has revealed new information about the cultural situation in the pre-Columbian and historic North American Southwest

Anticancer Activities of Resveratrol in Colorectal Cancer

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a dietary polyphenolic phytochemical that has demonstrated health benefits such as cardioprotection, the prevention of neurodegeneration and chemoprevention. Resveratrol has shown great potential in the prevention and treatment of carcinomas and clinical trials support resveratrol as anticancer compound in colorectal carcinoma. Colorectal cancer remains a major cause of cancer-related deaths for both men and women in industrialized countries. Because of this widespread prevalence, identifying major risk factors and initiating colorectal screening procedures provide the distinct advantage for recognizing early disease and addressing treatable forms of CRC. Epidemiological studies of fruit and vegetable consumption in relationship to developing CRC have led to the notion that safe and inexpensive chemopreventive agents might be a valuable tool in diminishing the morbidity and mortality of CRC. While clinical trials and in vivo data show positive effects of resveratrol in CRC, the mechanism of action is relatively unclear. In this review, we will evaluate the current literature on the actions of resveratrol in CRC and provide a more mechanistic view of resveratrol in relationship with CRC

Accounting students' expectations and transition experiences of supervised work experience

Political and economic discourses position employability as a responsibility of higher education, which utilise mechanisms such as supervised work experience (SWE) to embed employability into the undergraduate curriculum. However, sparse investigation of students' contextualised experiences of SWE results in little being known about the mechanisms through which students derive employability benefits from SWE. The aim of this study is to examine the impact of students' expectation and conception of workplace learning on their transition into SWE. Analysis of accounting students' experiences reveal two broad conceptions of workplace learning, the differing impacts of which on transition experience are explored using existing learning transfer perspectives. Students displaying the more common 'technical' conception construct SWE as an opportunity to develop technical, knowledge-based expertise and abilities that prioritize product-based or cognitive learning transfer. Students with an 'experiential' conception were found to construct SWE primarily as an experience through which the development of personal skills and abilities beyond technical expertise are prioritized using process-based or socio-cultural learning transfer. Further data analysis suggests that these two learning transfer approaches have differing impacts on students' employability development which may indicate a need for universities to consider how to develop appropriate student expectations of and approaches to SWE and meaningful support for students' SWE transition

Application of Open-Access Databases to Determine Functional Connectivity Between Resveratrol-Binding Protein QR2 and Colorectal Carcinoma

Colorectal cancer (CRC) is a major cause of cancer-associated deaths worldwide. Recently, oral administration of resveratrol (trans-3,5,4\u27-trihydroxystilbene) has been reported to significantly reduce tumor proliferation in colorectal cancer patients, however, with little specific information on functional connections. The pathogenesis and development of colorectal cancer is a multistep process that can be categorized using three phenotypic pathways, respectively, chromosome instability (CIN), microsatellite instability (MSI), and CpG island methylator (CIMP). Targets of resveratrol, including a high-affinity binding protein, quinone reductase 2 (QR2), have been identified with little information on disease association. We hypothesize that the relationship between resveratrol and different CRC etiologies might be gleaned using publicly available databases. A web-based microarray gene expression data-mining platform, Oncomine, was selected and used to determine whether QR2 may serve as a mechanistic and functional biotarget within the various CRC etiologies. We found that QR2 messenger RNA (mRNA) is overexpressed in CRC characterized by CIN, particularly in cells showing a positive KRAS (Kirsten rat sarcoma viral oncogene homolog) mutation, as well as by the MSI but not the CIMP phenotype. Mining of Oncomine revealed an excellent correlation between QR2 mRNA expression and certain CRC etiologies. Two resveratrol-associated genes, adenomatous polyposis coli (APC) and TP53, found in CRC were further mined, using cBio portal and Colorectal Cancer Atlas which predicted a mechanistic link to exist between resveratrol→QR2/TP53→CIN. Multiple web-based data mining can provide valuable insights which may lead to hypotheses serving to guide clinical trials and design of therapies for enhanced disease prognosis and patient survival. This approach resembles a BioGPS, a capability for mining web-based databases that can elucidate the potential links between compounds to provide correlations of these interactions with specific diseases